Pre_GI Gene

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Host: NC_004917 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004917:946550 Helicobacter hepaticus ATCC 51449, complete genome

Host Lineage: Helicobacter hepaticus; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This organism was found to be linked to an increasing incidence of liver tumors in mouse colonies at the National Cancer Institute in 1992. Normally it resides in the lower intestines, but it can cause chronic hepatitis. This organism has a similar urease gene cluster and cytolethal distending toxin as compared to Helicobacter pylori, but lacks other virulence factors such as the vacuolating cytotoxin and the cag pathogenicity island. However, it does contain a pathogenicity island that encodes proteins similar to those found in a type IV secretion system. Causes liver disease. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). This species was associated with an increase in liver tumors. It can cause active chronic hepatitis and typhlitis (inflammation of a region at the beginning of the large intestine), hepatocellular tumors, and gastric bowel disease in various mice strains.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
9465509479381389coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
947953948384432hypothetical protein
948388949377990ornithine carbamoyltransferaseQuickGO ontologyBLASTP
949453950025573hypothetical protein
950049950747699hypothetical proteinBLASTP
951092951847756hypothetical proteinBLASTP
9518379528381002hypothetical proteinBLASTP
9531849533151325S ribosomal RNAQuickGO ontology
953460956339288023S ribosomal RNAQuickGO ontologyBLASTP
95652195659373tRNA-AlaQuickGO ontology
95663995671274tRNA-IleQuickGO ontology
956872958328145716S ribosomal RNAQuickGO ontologyBLASTP
958823959767945lipid A biosynthesis lauroyl acyltransferaseQuickGO ontologyBLASTP
9597679608611095lipopolysaccharide heptosyltransferaseQuickGO ontologyBLASTP
9608859623571473exopolyphosphataseQuickGO ontologyBLASTP
962357962608252ferredoxinQuickGO ontologyBLASTP
962680963330651hypothetical proteinBLASTP
963348963455108hypothetical protein
963965964069105hypothetical protein
964113965051939hypothetical proteinBLASTP
9650089662701263hypothetical proteinBLASTP
9663219674211101hypothetical proteinBLASTP
9674459696822238conserved hypothetical outer membrane proteinQuickGO ontologyBLASTP