Pre_GI Gene

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Host: NC_004917 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004917:366104 Helicobacter hepaticus ATCC 51449, complete genome

Host Lineage: Helicobacter hepaticus; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This organism was found to be linked to an increasing incidence of liver tumors in mouse colonies at the National Cancer Institute in 1992. Normally it resides in the lower intestines, but it can cause chronic hepatitis. This organism has a similar urease gene cluster and cytolethal distending toxin as compared to Helicobacter pylori, but lacks other virulence factors such as the vacuolating cytotoxin and the cag pathogenicity island. However, it does contain a pathogenicity island that encodes proteins similar to those found in a type IV secretion system. Causes liver disease. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). This species was associated with an increase in liver tumors. It can cause active chronic hepatitis and typhlitis (inflammation of a region at the beginning of the large intestine), hepatocellular tumors, and gastric bowel disease in various mice strains.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
365665366117453hypothetical protein
3661043683262223recombination and DNA strand exchange inhibitor proteinQuickGO ontologyBLASTP
368393369136744hypothetical protein
369136369429294hypothetical protein
369445369915471predicted rRNA methylase SpoU classQuickGO ontologyBLASTP
3700653716391575anaerobic C4-dicarboxylate transporterQuickGO ontologyBLASTP
3716913727281038UDP-glucose 4-epimeraseQuickGO ontologyBLASTP
372745373503759hypothetical proteinBLASTP
3735143745211008hypothetical proteinBLASTP
3745483759211374hypothetical proteinBLASTP
376094376621528hypothetical proteinBLASTP
376621377163543hypothetical proteinBLASTP
377153377800648hypothetical proteinBLASTP
377800378363564hypothetical proteinBLASTP
378353378733381hypothetical proteinBLASTP
378733379086354hypothetical protein
379101379646546hypothetical proteinBLASTP
379627380208582hypothetical proteinBLASTP
380201380680480hypothetical proteinBLASTP
380691381185495hypothetical proteinBLASTP
381160381522363hypothetical proteinBLASTP
381504382451948hypothetical protein
3826303845311902acetyl-CoA synthetaseQuickGO ontologyBLASTP
384535385410876carboxyphosphoenolpyruvate phosphomutase PrpBQuickGO ontologyBLASTP
3854213865691149citrate synthase PrpCQuickGO ontologyBLASTP
38660338806014582-methylcitrate dehydrataseQuickGO ontologyBLASTP
388108388623516hypothetical protein
388738389253516hypothetical protein
389536389691156hypothetical protein
389688390569882hypothetical protein