Pre_GI Gene

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Host: NC_004851 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004851:191709 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
191493303IS2 ORF2QuickGO ontologyBLASTP
485949465putative resolvaseQuickGO ontologyBLASTP
191709192551843putative carbohydrate transport proteinQuickGO ontologyBLASTP
1925541936421089UDP-sugar hydrolaseQuickGO ontologyBLASTP
193647194597951VirK required for proper localization of IcsA VirG at the surface of bacteriaQuickGO ontologyBLASTP
194662195606945lipid A biosynthesis lauroyl acyltransferaseQuickGO ontologyBLASTP
195760196716957IS630 ORFQuickGO ontologyBLASTP
197582197884303IS600 ORF1QuickGO ontologyBLASTP
197923198108186DNA transport proteinQuickGO ontologyBLASTP
198108198827720hypothetical proteinBLASTP
198117198515399plasmid maintenance proteinQuickGO ontologyBLASTP
198515198742228plasmid maintenance proteinQuickGO ontologyBLASTP
198803199195393oriT nicking and unwinding proteinQuickGO ontologyBLASTP
1992162005801365oriT nicking and unwinding proteinQuickGO ontologyBLASTP
2005772040773501oriT nicking and unwinding proteinQuickGO ontologyBLASTP
204097204843747F pilin acetylation proteinQuickGO ontologyBLASTP
204898205458561FinO putative fertility inhibition proteinQuickGO ontologyBLASTP
205589205801213hypothetical proteinBLASTP
205985206287303hypothetical proteinBLASTP
206328207146819IS600 ORF2QuickGO ontologyBLASTP
207182207484303IS600 ORF1QuickGO ontologyBLASTP
207606207773168hypothetical proteinBLASTP
208067208657591hypothetical proteinBLASTP
208897209157261RepB replication proteinQuickGO ontologyBLASTP
20938120945575TapAQuickGO ontology
209448210305858RepA replication proteinQuickGO ontologyBLASTP
211006211197192hypothetical proteinBLASTP
2114272126231197IS1294 transposaseQuickGO ontologyBLASTP
212633212821189IS1294 transposaseQuickGO ontologyBLASTP
212967213134168putative transposaseQuickGO ontologyBLASTP
2131522148791728invasion plasmid antigen secreted by the Mxi-Spa secretion machineryQuickGO ontologyBLASTP
216182216334153hypothetical protein
216373216756384IS600 ORF1QuickGO ontologyBLASTP
216790217128339IS911 ORF1QuickGO ontologyBLASTP
217155217994840IS911 ORF2QuickGO ontologyBLASTP
218767218919153IS3 ORF2QuickGO ontologyBLASTP
220300221247948IcsP SopA outermembrane protease of the OmpP family involved in cleavage of surface exposed IcsAQuickGO ontologyBLASTP
221216221383168IS629 ORF1QuickGO ontologyBLASTP