Pre_GI Gene

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Host: NC_004851 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004851:157675 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
157675158478804putative reverse transcriptaseQuickGO ontologyBLASTP
158491158691201IS600 ORF2QuickGO ontologyBLASTP
159087159836750PhoN1 periplasmic non specific acid ohosphataseQuickGO ontologyBLASTP
160006160395390ISSfl1 ORF2QuickGO ontologyBLASTP
160401160850450ISSfl1 ORF1QuickGO ontologyBLASTP
160896161276381hypothetical proteinBLASTP
161459161854396plasmid stable inheritance proteinQuickGO ontologyBLASTP
161854162813960plasmid stable inheritance proteinQuickGO ontologyBLASTP
163184164155972hypothetical proteinBLASTP
164152164463312hypothetical proteinBLASTP
164527165210684hypothetical proteinBLASTP
165211165432222hypothetical proteinBLASTP
165429165629201hypothetical proteinBLASTP
165663165878216hypothetical proteinBLASTP
165923166693771hypothetical proteinBLASTP
167032167685654putative transposaseQuickGO ontologyBLASTP
1677601693611602ISSfl4 ORF3QuickGO ontologyBLASTP
169358169708351ISSfl4 ORF2QuickGO ontologyBLASTP
169705170379675ISSfl4 ORF1QuickGO ontologyBLASTP
170327171064738IS2 ORF2QuickGO ontologyBLASTP
171135171545411insertion sequence 2 OrfA proteinQuickGO ontologyBLASTP
171972172610639hypothetical proteinBLASTP
172967173239273iso-IS1 ORF1QuickGO ontologyBLASTP
173438174112675ISSfl4 ORF1QuickGO ontologyBLASTP
174109174456348ISSfl4 ORF2QuickGO ontologyBLASTP
1744761760771602ISSfl4 ORF3QuickGO ontologyBLASTP
176266176499234IS100 ORF2QuickGO ontologyBLASTP
176551176841291hypothetical proteinBLASTP
176810177061252hypothetical proteinBLASTP
177513177797285hypothetical proteinBLASTP
177797178072276hypothetical proteinBLASTP
178125178304180hypothetical protein
178298178801504IS1 ORF2QuickGO ontologyBLASTP
178876179178303putative IS1 encoded proteinQuickGO ontologyBLASTP
179387179605219putative protein encoded within ISQuickGO ontologyBLASTP
179624180004381ISSfl4 ORF3QuickGO ontologyBLASTP