Pre_GI Gene

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Host: NC_004719 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004719:5500 Streptomyces avermitilis MA-4680 plasmid SAP1, complete sequence

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil.The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
64957088594hypothetical proteinBLASTP
71117851741putative transposase B homologQuickGO ontologyBLASTP
87299040312hypothetical protein
92609592333hypothetical protein
962310216594hypothetical proteinBLASTP
1034610654309hypothetical protein
1074111103363hypothetical proteinBLASTP
1110611633528hypothetical proteinBLASTP
1165712223567hypothetical protein
12286135661281putative endonuclease VIIQuickGO ontologyBLASTP
13703150611359hypothetical proteinBLASTP
15071171042034putative NHN endonucleaseQuickGO ontologyBLASTP
1756018426867putative acetyltransferaseQuickGO ontology
1879619674879hypothetical proteinBLASTP
1976820325558putative terminal protein TpgA2QuickGO ontologyBLASTP
20338226562319putative transcriptional regulatory proteinQuickGO ontologyBLASTP
22760245981839putative DNA-binding proteinQuickGO ontologyBLASTP
2456224840279hypothetical protein