Pre_GI Gene

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Host: NC_004671 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004671:1 Enterococcus faecalis V583 plasmid pTEF2, complete sequence

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10011101011replication-associated protein RepAQuickGO ontologyBLASTP
128024371158pheromone shutdown protein TraBQuickGO ontologyBLASTP
248640751590TraC proteinQuickGO ontologyBLASTP
41015042942transcriptional regulator CroCI familyQuickGO ontology
5255533278hypothetical protein
58226202381probable pheromone-responsive regulatory protein RQuickGO ontology
67766964189hypothetical proteinBLASTP
69687081114hypothetical proteinBLASTP
709297672676surface exclusion protein PrgAQuickGO ontologyBLASTP
9960138773918aggregation substance PrgBQuickGO ontologyBLASTP
1432315180858surface protein PrgCQuickGO ontologyBLASTP
1522216121900hypothetical proteinBLASTP