Pre_GI Gene

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Host: NC_004669 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004669:24672 Enterococcus faecalis V583 plasmid pTEF1, complete sequence

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
24672271642493hypothetical proteinBLASTP
2726927727459single-strand binding proteinQuickGO ontologyBLASTP
2788428285402hypothetical protein
2827328548276hypothetical protein
28538295721035hypothetical protein
2956529879315hypothetical protein
2987930295417hypothetical proteinBLASTP
3027930896618hypothetical protein
30899321701272hypothetical proteinBLASTP
3219633056861cell wall surface anchor signal proteinQuickGO ontologyBLASTP
3307633954879hypothetical proteinBLASTP
3396534225261hypothetical protein
3429434680387hypothetical protein
3470235055354hypothetical protein
35117390073891aggregation substance Asa1QuickGO ontologyBLASTP
3931439649336hypothetical protein
398783997093hypothetical protein
3998940174186hypothetical protein
40246429182673surface exclusion protein Sea1QuickGO ontologyBLASTP
4292943234306hypothetical proteinBLASTP
4381644172357regulatory protein TraE1QuickGO ontology