Pre_GI Gene

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Host: NC_004631 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004631:531254 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5312545326451392phosphoglycerate transporter proteinQuickGO ontologyBLASTP
5330815342741194phosphoglycerate transport regulatory protein PgtC precursorQuickGO ontologyBLASTP
5342715362772007phosphoglycerate transport system sensor protein PgtBQuickGO ontologyBLASTP
5362675375141248phosphoglycerate transport system transcriptional regulatory protein PgtAQuickGO ontologyBLASTP
537782538720939outer membrane protease EQuickGO ontologyBLASTP
5402015421231923putative lipopolysaccharide modification acyltransferaseQuickGO ontologyBLASTP
542363542752390bactoprenol-linked glucose transferaseQuickGO ontologyBLASTP
543995544936942hypothetical proteinBLASTP
545225545980756VacJ lipoprotein precursorQuickGO ontologyBLASTP
5460415473541314long-chain fatty acid transport protein precursorQuickGO ontologyBLASTP
547719548003285hypothetical proteinBLASTP
5481815494911311acetyl-CoA acetyltransferaseQuickGO ontologyBLASTP
5494915516382148putative fatty acid oxidation complex alpha subunitQuickGO ontologyBLASTP
551847552332486phosphohistidine phosphataseQuickGO ontologyBLASTP
552381552932552hypothetical proteinBLASTP
553098554030933hypothetical proteinBLASTP
5540665551511086chorismate synthaseQuickGO ontologyBLASTP