Pre_GI Gene

Some Help

Host: NC_004631 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004631:4494000 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
449416944961391971Vi polysaccharide export proteinQuickGO ontologyBLASTP
449615944974631305Vi polysaccharide export inner-membrane proteinQuickGO ontologyBLASTP
44974864498181696Vi polysaccharide export ATP-binding proteinQuickGO ontologyBLASTP
44982074499001795Vi polysaccharide export inner-membrane proteinQuickGO ontologyBLASTP
449901145000781068Vi polysaccharide export proteinQuickGO ontologyBLASTP
450012345018591737Vi polysaccharide biosynthesis protein TviEQuickGO ontologyBLASTP
450185945043542496Vi polysaccharide biosynthesis proteinQuickGO ontologyBLASTP
450437845054241047Vi polysaccharide biosynthesis protein epimeraseQuickGO ontologyBLASTP
450542745067041278Vi polysaccharide biosynthesis protein UDP-glucoseGDP-mannose dehydrogenaseQuickGO ontologyBLASTP
45069494507488540Vi polysaccharide biosynthesis proteinQuickGO ontologyBLASTP
45080294508217189hypothetical proteinBLASTP
450834245098531512putative DNA helicaseQuickGO ontologyBLASTP
450983745114261590hypothetical proteinBLASTP
451159045126031014probable phage integraseQuickGO ontologyBLASTP
45130304513323294hypothetical proteinBLASTP
45133204513808489hypothetical proteinBLASTP