Pre_GI Gene

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Host: NC_004631 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004631:3841975 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
384197538429881014hypothetical proteinBLASTP
38431423843732591two-component system response regulator proteinQuickGO ontologyBLASTP
384373238452341503two-component system sensor histidine kinaseQuickGO ontologyBLASTP
384524438465721329regulatory proteinQuickGO ontologyBLASTP
384671538481061392hexosephosphate transport proteinQuickGO ontologyBLASTP
38482933848751459hypothetical proteinBLASTP
38491043849847744putative GntR-family transcriptional regulatorQuickGO ontologyBLASTP
38498653850245381hypothetical proteinBLASTP
38503353850622288putative IIB component of PTS systemQuickGO ontologyBLASTP
385069838520561359putative IIC component of PTS systemQuickGO ontologyBLASTP
385204938535331485putative carbohydrate kinaseQuickGO ontologyBLASTP
38544663854735270putative phosphocarrier protein of PTS systemQuickGO ontologyBLASTP
38548263855149324putative DNA-binding proteinQuickGO ontologyBLASTP
385570738569001194putative inner membrane transport proteinQuickGO ontologyBLASTP
385696038583421383putative glycosyl hydrolaseQuickGO ontologyBLASTP
38584483858741294putative secreted proteinQuickGO ontologyBLASTP
38619593862384426putative PTS system proteinQuickGO ontologyBLASTP
38623953862880486putative PTS system proteinQuickGO ontologyBLASTP
38630263863775750putative PTS system proteinQuickGO ontologyBLASTP
38637753864632858putative PTS system proteinQuickGO ontologyBLASTP