Pre_GI Gene

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Host: NC_004631 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004631:2872192 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
28715282872202675virulence-associated secretory proteinQuickGO ontologyBLASTP
28721922873103912type III secretion proteinQuickGO ontologyBLASTP
287310328741131011antigen presentation protein SpaNQuickGO ontologyBLASTP
28741132874556444virulence-associated secretory proteinQuickGO ontologyBLASTP
287453428758291296type III secretion system ATPaseQuickGO ontologyBLASTP
28758262876233408virulence-associated secretory proteinQuickGO ontologyBLASTP
287625728783142058possible virulence-associated secretory proteinQuickGO ontologyBLASTP
287833928794571119cell invasion proteinQuickGO ontologyBLASTP
287945428811421689virulence-associated secretory proteinQuickGO ontologyBLASTP
28811392881789651possible AraC-family regulatory proteinQuickGO ontologyBLASTP
28822452882688444cell adheranceinvasion proteinQuickGO ontologyBLASTP
28835622883852291hypothetical proteinBLASTP
28838492884376528hypothetical proteinBLASTP
28850972885753657possible serinethreonine protein phosphataseQuickGO ontologyBLASTP
28859232886108186hypothetical proteinBLASTP
28861172886443327hypothetical proteinBLASTP
288660128891682568DNA mismatch repair proteinQuickGO ontologyBLASTP
28892242889520297hypothetical proteinBLASTP
288960428908121209possible membrane transport proteinQuickGO ontologyBLASTP
28909002891832933possible LysR-family transcriptional regulatorQuickGO ontologyBLASTP
289187428933701497possible permeaseQuickGO ontologyBLASTP
28933672894317951hypothetical proteinBLASTP