Pre_GI Gene

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Host: NC_004631 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004631:2755306 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
275530627564211116putative glycosyl transferaseQuickGO ontologyBLASTP
275650227601583657putative ABC transporter proteinQuickGO ontologyBLASTP
276026827615121245putative ferric enterochelin esteraseQuickGO ontologyBLASTP
27615442762461918hypothetical proteinBLASTP
276252127647012181TonB-dependent outer membrane siderophore receptor proteinQuickGO ontologyBLASTP
27650312765273243hypothetical proteinBLASTP
276572327667751053hypothetical proteinBLASTP
27672922768221930virulence proteinQuickGO ontologyBLASTP
27685152769411897putative transcriptional regulatorQuickGO ontologyBLASTP
277127927726941416putative two-component system sensor kinaseQuickGO ontologyBLASTP
27726812773355675transcriptional regulatorQuickGO ontologyBLASTP
27733942773513120hypothetical proteinBLASTP
27735102774319810hypothetical proteinBLASTP
27743342774765432hypothetical proteinBLASTP
277477627762901515hypothetical proteinBLASTP
27765842777570987hypothetical proteinBLASTP
277759627788641269putative GAB DTP gene cluster repressorQuickGO ontologyBLASTP