Pre_GI Gene

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Host: NC_004631 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004631:2615908 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
26159082616486579phosphoheptose isomeraseQuickGO ontologyBLASTP
261672626191702445acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
26192792620046768possible hydrolaseQuickGO ontologyBLASTP
26203562620763408probable secreted proteinQuickGO ontologyBLASTP
26210882621807720possible outer membrane adhesinQuickGO ontologyBLASTP
26227702623387618hypothetical proteinBLASTP
26235272623982456transcriptional regulatorQuickGO ontologyBLASTP
262411526251941080putative fimbrail proteinQuickGO ontologyBLASTP
262521726279042688outer membrane fimbrial user proteinQuickGO ontologyBLASTP
26280132628588576putative fimbrial subunitQuickGO ontologyBLASTP
26286392629349711putative fimbrial proteinQuickGO ontologyBLASTP
26312542631367114hypothetical proteinBLASTP
26314872632431945LysR-family transcriptional regulator SinRQuickGO ontologyBLASTP
26332492634070822hypothetical proteinBLASTP
26344782634948471putative fimbrial structural subunitQuickGO ontologyBLASTP
263497026374802511outer-membrane fimbrial usher proteinQuickGO ontologyBLASTP
26375042638244741periplasmic fimbrial chaperone proteinQuickGO ontologyBLASTP