Pre_GI Gene

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Host: NC_004631 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004631:2584244 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
258424425862021959Type III restriction-modification system StyLTI enzyme modQuickGO ontologyBLASTP
258639125876441254putative metabolite transport proteinQuickGO ontologyBLASTP
25877362587891156hypothetical proteinBLASTP
25878372588304468hypothetical proteinBLASTP
25888862589245360probable lipoproteinQuickGO ontologyBLASTP
25893032589527225probable secreted proteinQuickGO ontologyBLASTP
25895382590065528possible transcriptionl regulatorQuickGO ontologyBLASTP
25903252590849525possible outer membrane proteinQuickGO ontologyBLASTP
25911902591738549hypothetical proteinBLASTP
25917112592454744possible transmembrane regulatorQuickGO ontologyBLASTP
259255425941281575putative rtn proteinQuickGO ontologyBLASTP
25944402594769330hypothetical proteinBLASTP
25949142595648735possible transmembrane regulatorQuickGO ontologyBLASTP
25963112596847537probable fimbrial proteinQuickGO ontologyBLASTP
25969092597670762fimbrial chaperone proteinQuickGO ontologyBLASTP
260022026015451326putative fimbrial proteinQuickGO ontologyBLASTP
26015112602269759fimbrial chaperone proteinQuickGO ontologyBLASTP
26023172602715399probable secreted proteinQuickGO ontologyBLASTP
2602939260301476tRNA-ThrQuickGO ontologyBLASTP
260313026043801251gamma-glutamyl phosphate reductaseQuickGO ontologyBLASTP
260439226054951104gamma-glutamyl kinaseQuickGO ontologyBLASTP