Pre_GI Gene

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Host: NC_004631 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004631:25807 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
28429294361008fimbrial subunitQuickGO ontologyBLASTP
2943729982546fimbrial subunitQuickGO ontologyBLASTP
2999830516519fimbrial subunitQuickGO ontologyBLASTP
3050931213705fimbrial chaperoneQuickGO ontologyBLASTP
3127832123846hypothetical proteinBLASTP
3216232449288hypothetical proteinBLASTP
3254932998450hypothetical proteinBLASTP
3336834363996putative transcriptional regulator lysR familyQuickGO ontologyBLASTP
3451134816306putative transcriptional regulatorQuickGO ontologyBLASTP
35339370571719possible sulfataseQuickGO ontologyBLASTP
37103386741572putative secreted 5-nucleotidaseQuickGO ontologyBLASTP
3877339534762hypothetical proteinBLASTP
40128416211494putative secreted sulfataseQuickGO ontologyBLASTP
41720429101191possible sulfatase regulatory proteinQuickGO ontologyBLASTP
4319844181984hypothetical proteinBLASTP
44308460231716possible sulfataseQuickGO ontologyBLASTP
46186473521167NaH antiporter 1QuickGO ontologyBLASTP
4741448313900transcriptional activator protein NhaRQuickGO ontologyBLASTP