Pre_GI Gene

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Host: NC_004631 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004631:2366335 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
23663352366775441hypothetical proteinBLASTP
23668542367414561hypothetical proteinBLASTP
23674272367663237hypothetical secreted proteinQuickGO ontologyBLASTP
236782023691451326pyridine nucleotide-disulfide oxidoreductaseQuickGO ontologyBLASTP
23693612370215855hypothetical araC-family transcriptional regulatorQuickGO ontologyBLASTP
23707752371020246possible copper-binding proteinQuickGO ontologyBLASTP
23714232371785363bactoprenol-linked glucose translocaseQuickGO ontologyBLASTP
23717822372708927bactoprenol glucosyltransferaseQuickGO ontologyBLASTP
237270123743411641hypothetical proteinBLASTP
23758412376437597fimbriae w proteinQuickGO ontologyBLASTP
23765992376910312hypothetical proteinBLASTP
23769292377651723fimbriae Y proteinQuickGO ontologyBLASTP
23782552378887633probable transcriptional regulatorQuickGO ontologyBLASTP
23789332379451519fimbria-like protein FimF precursorQuickGO ontologyBLASTP
237946123804681008FimH protein precursorQuickGO ontologyBLASTP
238048323830952613outer membrane usher protein FimD precursorQuickGO ontologyBLASTP
23831262383818693fimbrial chaperone proteinQuickGO ontologyBLASTP
23838622384395534hypothetical proteinBLASTP
23844702385024555Type-1 fimbrial protein a chain precursorQuickGO ontologyBLASTP
23855712386437867methenyltetrahydrofolate cyclohydrolaseQuickGO ontologyBLASTP
23864392386651213hypothetical proteinBLASTP
23867352387283549hypothetical proteinBLASTP