Pre_GI Gene

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Host: NC_004631 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004631:2205821 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
220582122075871767succinate dehydrogenase catalytic subunitQuickGO ontologyBLASTP
22075872207934348succinate dehydrogenase cytochrome b556 small membrane subunitQuickGO ontologyBLASTP
22079282208317390succinate dehydrogenase cytochrome b556 large membrane subunitQuickGO ontologyBLASTP
22087262208971246hypothetical proteinBLASTP
220907222103551284citrate synthaseQuickGO ontologyBLASTP
221049222115381047hypothetical proteinBLASTP
22115932212384792endonuclease VIIIQuickGO ontologyBLASTP
22124182212570153hypothetical proteinBLASTP
22141182214951834hypothetical proteinBLASTP
22170172217727711putative polysaccharide export ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
221863022197631134galactosyltransferaseQuickGO ontologyBLASTP
22197762220669894putative glycosyl transferaseQuickGO ontologyBLASTP
222075222218461095UDP-galactopyranose mutaseQuickGO ontologyBLASTP
22221052222845741hypothetical proteinBLASTP
22228472223182336hypothetical proteinBLASTP
22233602223926567probable DNA recombinaseQuickGO ontologyBLASTP
22239862224117132hypothetical proteinBLASTP
22244412225175735hypothetical proteinBLASTP
22251652226097933hypothetical proteinBLASTP
22260912226747657hypothetical proteinBLASTP
22267632227506744hypothetical proteinBLASTP
222783522293161482PTR2-family transport proteinQuickGO ontologyBLASTP
222935522307761422deoxyribodipyrimidine photolyaseQuickGO ontologyBLASTP
22308872231093207hypothetical proteinBLASTP
223151922331981680potassium-transporting ATPase subunit AQuickGO ontologyBLASTP