Pre_GI Gene

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Host: NC_004631 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004631:1881214 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1881214188250312902-hydroxyhepta-24-diene-17-dioate decarboxylaseQuickGO ontologyBLASTP
18827781883218441homoprotocatechuate degradative operon repressorQuickGO ontologyBLASTP
1883324188463113084-hydroxyphenylacetate 3-monooxygenaseQuickGO ontologyBLASTP
188464918851615134-hydroxyphenylacetate 3-monooxygenase coupling proteinQuickGO ontologyBLASTP
18854941885904411hypothetical proteinBLASTP
18859741886720747response regulatorQuickGO ontologyBLASTP
188671318880771365histidine kinaseQuickGO ontologyBLASTP
188825018897191470putative secreted peptidaseQuickGO ontologyBLASTP
18898281889938111hypothetical proteinBLASTP
18899391890109171hypothetical proteinBLASTP
189044118921261686cell invasion proteinQuickGO ontologyBLASTP
18921431892484342cell invasion proteinQuickGO ontologyBLASTP
18930321893907876hypothetical proteinBLASTP
18941301894810681hypothetical proteinBLASTP
18950181895476459transposase for insertion sequence element IS200QuickGO ontologyBLASTP
1895658189574588tRNA-SerQuickGO ontologyBLASTP
18961401896799660hypothetical proteinBLASTP
18968861897215330hypothetical protein in helD-serT intergenic regionQuickGO ontologyBLASTP
18972121897493282putative acylphosphataseQuickGO ontologyBLASTP
18982301898688459transposase for insertion sequence element IS200QuickGO ontologyBLASTP
189982019010311212hypothetical proteinBLASTP
19010891901406318hypothetical proteinBLASTP
19014511901867417hypothetical proteinBLASTP
19020381902700663hypothetical proteinBLASTP
19027951903253459methylglyoxal synthaseQuickGO ontologyBLASTP
190328919053432055helicase IVQuickGO ontologyBLASTP