Pre_GI Gene

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Host: NC_004631 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004631:1842050 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18420501842883834assemblytransport component in curli productionQuickGO ontologyBLASTP
18429211843451531hypothetical proteinBLASTP
18435041844058555hypothetical proteinBLASTP
18440821844819738hypothetical proteinBLASTP
18449041845842939putative 2-hydroxyacid dehydrogenase in phoh-csgg intergenic regionQuickGO ontologyBLASTP
1846078184616588tRNA-SerQuickGO ontologyBLASTP
184668718477901104putative oxidoreductaseQuickGO ontologyBLASTP
184780418490841281putative sialic acid transporterQuickGO ontologyBLASTP
18493671850059693putative secreted proteinQuickGO ontologyBLASTP
185010518512591155hypothetical proteinBLASTP
18517661852446681hypothetical proteinBLASTP
18527831853310528putative membrane transporterQuickGO ontologyBLASTP
18534231854280858putative membrane transporterQuickGO ontologyBLASTP
18545661855447882putative transcriptional regulatorQuickGO ontologyBLASTP
18555531856407855PhoH proteinQuickGO ontologyBLASTP
185723418587421509sodiumproline symporterQuickGO ontologyBLASTP
185916418631263963proline dehydrogenaseQuickGO ontologyBLASTP