Pre_GI Gene

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Host: NC_004631 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004631:1325817 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
132581713275951779hypothetical proteinBLASTP
13275701328190621putative two-component response regulatorQuickGO ontologyBLASTP
13282881328500213hypothetical proteinBLASTP
13285961329555960putative pathogenicity island proteinQuickGO ontologyBLASTP
13297271330455729putative transcriptional regulatorQuickGO ontologyBLASTP
13306341331272639putative two-component response regulatorQuickGO ontologyBLASTP
133130313340652763putative two-component sensor kinaseQuickGO ontologyBLASTP
13344841334867384putative pathogenicity island secreted effector proteinQuickGO ontologyBLASTP
133486913363621494putative outer membrane secretory proteinQuickGO ontologyBLASTP
133634313375541212putative pathogenicity island proteinQuickGO ontologyBLASTP
13375621337804243putative secretion system proteinQuickGO ontologyBLASTP
13380071338333327putative pathogenicity island proteinQuickGO ontologyBLASTP
13383401338930591putative pathogenicity island effector proteinQuickGO ontologyBLASTP
13389271339400474putative type III secretion system chaperone proteinQuickGO ontologyBLASTP
133940313408571455putative pathogenicity island effector proteinQuickGO ontologyBLASTP
13408731341460588putative pathogenicity island effector proteinQuickGO ontologyBLASTP
13414631341879417putative pathogenicity island effector proteinQuickGO ontologyBLASTP
13419311342365435putative pathogenicity island proteinQuickGO ontologyBLASTP
13423811343163783putative pathogenicity island effector proteinQuickGO ontologyBLASTP
13431601343849690putative pathogenicity island effector proteinQuickGO ontologyBLASTP
13439431344158216putative pathogenicity island proteinQuickGO ontologyBLASTP
13441991344426228putative pathogenicity island proteinQuickGO ontologyBLASTP
13444381344686249putative pathogenicity island proteinQuickGO ontologyBLASTP
13446831345432750putative pathogenicity island lipoproteinQuickGO ontologyBLASTP
13454501345998549putative pathogenicity island proteinQuickGO ontologyBLASTP
13459951346669675putative pathogenicity island proteinQuickGO ontologyBLASTP
13466591347651993putative secretion system proteinQuickGO ontologyBLASTP
13477091348077369putative pathogenicity island proteinQuickGO ontologyBLASTP
134806213501072046putative type III secretion proteinQuickGO ontologyBLASTP
135009713513981302type III secretion system ATPaseQuickGO ontologyBLASTP