Pre_GI Gene

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Host: NC_004631 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004631:1091303 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10913031092178876putative cation transporterQuickGO ontologyBLASTP
10921951092548354hypothetical proteinBLASTP
10926091092725117hypothetical proteinBLASTP
10937041093931228putative DNA-binding proteinQuickGO ontologyBLASTP
10940751094248174hypothetical proteinBLASTP
109438510955151131hypothetical proteinBLASTP
109591110978901980putative hydrolaseQuickGO ontologyBLASTP
10979081098099192hypothetical proteinBLASTP
10982991098913615hypothetical proteinBLASTP
10989231099081159hypothetical proteinBLASTP
10992141100128915hypothetical proteinBLASTP
11031641103340177hypothetical proteinBLASTP
11034731103739267hypothetical proteinBLASTP
11041101104529420putative acetyltransferaseQuickGO ontologyBLASTP
11049171105393477hypothetical proteinBLASTP
11057221106117396hypothetical proteinBLASTP
11078071107971165hypothetical proteinBLASTP
11081951108845651serinethreonine protein phosphatase 1QuickGO ontologyBLASTP
11088641109055192putative secreted proteinQuickGO ontologyBLASTP
11091661109405240hypothetical proteinBLASTP
110952011109591440hypothetical proteinBLASTP