Pre_GI Gene

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Host: NC_004565 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004565:20256 Clostridium tetani E88 plasmid pE88, complete sequence

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
20256219411686hypothetical protein
21961229891029putative aminopeptidaseQuickGO ontologyBLASTP
2380924495687two-component response regulatorQuickGO ontologyBLASTP
2452925473945two-component sensor histidine kinaseQuickGO ontologyBLASTP
2567126078408hypothetical protein
2610826866759ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
26853287811929ABC transporter-associated permeaseQuickGO ontologyBLASTP
2954230111570hypothetical protein
3033831174837rRNA guanine-N1- methyltransferase Mycinamicin-resistance proteinQuickGO ontologyBLASTP
3230332668366hypothetical protein
33162351021941hypothetical membrane-spanning proteinQuickGO ontology
3552136027507ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
3799038466477hypothetical protein