Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:81362 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
8136282177816hypothetical proteinBLASTP
823388241275tRNA-GluQuickGO ontology
824248249976tRNA-ValQuickGO ontologyBLASTP
825078258478tRNA-AspQuickGO ontology
825928266776tRNA-ThrQuickGO ontologyBLASTP
8277783766990DNA replication protein DnaCQuickGO ontologyBLASTP
8376384737975DNA replication protein dnaDQuickGO ontologyBLASTP
84888859551068hypothetical proteinBLASTP
8594886403456transcriptional regulator marR familyQuickGO ontologyBLASTP
864188742210053-oxoacyl-acyl carrier protein synthaseQuickGO ontologyBLASTP
8765688618963enoyl-acyl-carrier protein reductase NADHQuickGO ontologyBLASTP
8861189549939acyl-carrier-protein S-malonyltransferaseQuickGO ontologyBLASTP
89557903127563-ketoacyl-acyl-carrier-protein reductaseQuickGO ontologyBLASTP
903339157712453-oxoacyl-acyl carrier protein synthaseQuickGO ontologyBLASTP
9158092038459biotin carboxyl carrier protein of acetyl-coA carboxylaseQuickGO ontologyBLASTP
92073925014293R-hydroxymyristoyl ACP dehydrataseQuickGO ontologyBLASTP
92509938491341acetyl-CoA carboxylaseQuickGO ontologyBLASTP
93861955881728acetyl-coA carboxylase carboxyl transferase subunit betaalphaQuickGO ontologyBLASTP
9569696115420tranposase-likeQuickGO ontologyBLASTP
9611297032921transposaseQuickGO ontologyBLASTP
9710097609510ferritinQuickGO ontologyBLASTP
97682988751194intracellular alkaline serine proteaseQuickGO ontologyBLASTP
9895499421468hypothetical proteinBLASTP
9948499975492hypothetical proteinBLASTP
100302100904603conserved protein ferredoxin-relatedQuickGO ontologyBLASTP
1009601023511392asparaginyl-tRNA synthetaseQuickGO ontologyBLASTP
102883103350468acetyltransferaseQuickGO ontologyBLASTP
103488104177690cytochrome c-type biogenesis protein ccdAQuickGO ontologyBLASTP