Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:806878 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.


This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
8068788085841707putative surfacecell-adhesion proteinQuickGO ontologyBLASTP
8086628104731812putative surfacecell-adhesion protein big2 domainQuickGO ontologyBLASTP
8107428118661125putative surfacecell-adhesion proteinQuickGO ontologyBLASTP
8119028129841083putative surfacecell-adhesion proteinQuickGO ontologyBLASTP
8130058150082004N-acetylmuramoyl-L-alanine amidaseQuickGO ontologyBLASTP
8150588161191062internalin-likeN-acetylmuramoyl-L-alanine amidaseQuickGO ontologyBLASTP
8164028174691068putative surfacecell-adhesion proteinQuickGO ontologyBLASTP
8175568231985643putative surfacecell-adhesion proteinQuickGO ontologyBLASTP
823810824295486hypothetical proteinBLASTP
8244848262051722phosphoglucomutaseQuickGO ontologyBLASTP
826235827086852conserved protein with patatin domainQuickGO ontologyBLASTP
8274948285191026asparagine synthetase AsnAQuickGO ontologyBLASTP
828628829236609hypothetical proteinBLASTP
829233830090858ferric enterobactin transport ATP-binding protein fepCQuickGO ontologyBLASTP
8300928311441053ironIII dicitrate transport system permease protein fecDQuickGO ontologyBLASTP