Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:363628 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
363628364614987N5-carboxyethylornithine synthaseQuickGO ontologyBLASTP
3649443663291386DNA-directed RNA polymerase subunit NQuickGO ontologyBLASTP
3664713674991029putative central glycolytic genes regulatorQuickGO ontologyBLASTP
3675953686021008glyceraldehyde 3-phosphate dehydrogenaseQuickGO ontologyBLASTP
3687023699071206phosphoglycerate kinaseQuickGO ontologyBLASTP
369920370687768triosephosphate isomeraseQuickGO ontologyBLASTP
3706983722391542phosphoglyceromutaseQuickGO ontologyBLASTP
3722583735531296phosphopyruvate hydrataseQuickGO ontologyBLASTP
3740533760742022vacuolar-type H-pyrophosphataseQuickGO ontologyBLASTP
3762663783922127exoribonuclease IIQuickGO ontologyBLASTP
379026379496471SsrA-binding proteinQuickGO ontologyBLASTP
380624381466843putative adenine-specific DNA methyltransferaseQuickGO ontologyBLASTP
3814593827451287hypothetical proteinBLASTP
3829573839791023transposaseQuickGO ontologyBLASTP
3841033851821080hypothetical proteinBLASTP
385442385852411hypothetical protein
385961386656696two-component response regulatorQuickGO ontologyBLASTP
3866693877271059two-component sensor histidine kinaseQuickGO ontologyBLASTP