Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:2677155 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
267715526784561302NADH dehydrogenase similar to nitrite reductaseQuickGO ontologyBLASTP
26784752679323849ribonuclease BNQuickGO ontologyBLASTP
268002526813891365putative aldehyde dehydrogenase ywdHQuickGO ontologyBLASTP
26815032682450948carbamate kinaseQuickGO ontologyBLASTP
26826042683554951pyruvate synthase subunit porBQuickGO ontologyBLASTP
268356626847561191pyruvate synthase subunit porAQuickGO ontologyBLASTP
26847722685077306pyruvate synthase subunit porDQuickGO ontologyBLASTP
26850642685648585pyruvate synthase subunit porCQuickGO ontologyBLASTP
268567326870311359NaH antiporterQuickGO ontologyBLASTP
268711726883131197methionine gamma-lyaseQuickGO ontologyBLASTP
268851326900721560transcriptional regulatorQuickGO ontologyBLASTP
26902032691183981meso-diaminopimelate dehydrogenaseQuickGO ontologyBLASTP
26914122691783372hypothetical proteinBLASTP
26920022692418417hypothetical protein
26924242693107684ketoacyl reductase hetNQuickGO ontologyBLASTP
26931992693960762putative DNA polymerase betaQuickGO ontologyBLASTP
26939572694808852hypothetical proteinBLASTP
269481426961331320coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
26961552697003849hypothetical proteinBLASTP
269700026981931194hypothetical proteinBLASTP
26981352699019885hypothetical proteinBLASTP
26990732700071999hypothetical protein
270034827021801833D-fructose-6-phosphate amidotransferaseQuickGO ontologyBLASTP
270253627038821347phosphoglucosamine mutaseQuickGO ontologyBLASTP