Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:2475030 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
247503024762051176transglutaminase-like enzyme putative cysteine proteaseQuickGO ontologyBLASTP
24762402476890651RecA regulator RecXQuickGO ontologyBLASTP
247691824781981281zinc proteaseQuickGO ontologyBLASTP
24782912478815525transporterQuickGO ontologyBLASTP
24788412479737897glycine betaine-binding proteinQuickGO ontologyBLASTP
24797342480561828putative glycine-betaine binding permease proteinQuickGO ontologyBLASTP
248056624817501185glycine betaine transport ATP-binding proteinQuickGO ontologyBLASTP
248200024833521353spore cortex-lytic enzyme pre-pro-formQuickGO ontologyBLASTP
248341824863542937putative serine-type proteaseQuickGO ontologyBLASTP
24870192488017999catabolite control proteinQuickGO ontologyBLASTP
24881082488662555D-ribose-binding periplasmic proteinQuickGO ontologyBLASTP
24890712490021951ribose transport system permease protein rbsCQuickGO ontologyBLASTP
249003424915511518ribose transport ATP-binding protein rbsAQuickGO ontologyBLASTP
24915512491946396high affinity ribose transport protein rbsDQuickGO ontologyBLASTP
24919492492878930ribokinaseQuickGO ontologyBLASTP
24931202493731612transporterQuickGO ontologyBLASTP
24937992494302504putative phosphoesteraseQuickGO ontologyBLASTP
249449324957851293homoserine dehydrogenaseQuickGO ontologyBLASTP
249580924971281320aspartate kinaseQuickGO ontologyBLASTP
24971312498042912homoserine kinaseQuickGO ontologyBLASTP
249804324995361494threonine synthaseQuickGO ontologyBLASTP