Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:2289135 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
228913522903281194putative NaH antiporterQuickGO ontologyBLASTP
22912972292160864metal dependent hydrolaseQuickGO ontologyBLASTP
22923172292781465ethanolamine utilization protein transcriptional regulatorQuickGO ontologyBLASTP
229279622938871092ethanolamine permeaseQuickGO ontologyBLASTP
22939292294486558putative ethanolamine utilization proteinQuickGO ontologyBLASTP
22947972295552756putative ethanolamine utilization proteinQuickGO ontologyBLASTP
22955302296366837ethanolamine utilization protein eutJQuickGO ontologyBLASTP
22963782297028651putative ethanolamine utilization proteinQuickGO ontologyBLASTP
22970322297850819cobalamin adenosyltransferaseQuickGO ontologyBLASTP
229823522997071473ethanolamine utilization protein eutEQuickGO ontologyBLASTP
22997222300255534carbon dioxide concentrating mechanism proteinQuickGO ontologyBLASTP
23002702300926657ethanolamine utilization protein eutLQuickGO ontologyBLASTP
23009442301828885ethanolamine ammonia-lyase small subunitQuickGO ontologyBLASTP
230184323032191377ethanolamine ammonia-lyase heavy chainQuickGO ontologyBLASTP
230324923046821434ethanolamine utilization protein eutAQuickGO ontologyBLASTP
230483823062861449ethanolamine utilization sensory transduction histidine kinaseQuickGO ontologyBLASTP
23062702306848579ethanolamine utilization response regulatorQuickGO ontologyBLASTP
23069222307356435ethanolamine utilization protein eutPQuickGO ontologyBLASTP
23073672307720354ethanolamine utilization protein eutSQuickGO ontologyBLASTP
230790823090771170alcetaldehyde dehydrogenase or NADPH-dependent butanol dehydrogenaseQuickGO ontologyBLASTP
23092542310060807putative arylesterase similar to non-heme chloride peroxidaseQuickGO ontologyBLASTP
231030523114171113ATP-dependent RNA helicaseQuickGO ontologyBLASTP
23115042311908405glyoxalase IQuickGO ontology
23119422312616675homoserinehomoserine lactone efflux proteinQuickGO ontologyBLASTP
23125982313287690hypothetical protein