Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:2078000 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.


This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
20780142078748735NAD-dependent DNA ligaseQuickGO ontology
207834320802951953Zinc-transporting ATPaseQuickGO ontologyBLASTP
208062720825071881oligoendopeptidase FQuickGO ontologyBLASTP
208255420838731320histidyl-tRNA synthetaseQuickGO ontologyBLASTP
20840592085000942membrane associated proteinQuickGO ontologyBLASTP
20850182086013996membrane associated proteinQuickGO ontologyBLASTP
208623620874921257phosphoribosylamine--glycine ligaseQuickGO ontologyBLASTP
208750620890051500bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferaseIMP cyclohydrolaseQuickGO ontologyBLASTP
20890192089639621phosphoribosylglycinamide formyltransferaseQuickGO ontologyBLASTP
20896672090662996phosphoribosylaminoimidazole synthetaseQuickGO ontologyBLASTP
209068120920781398amidophosphoribosyltransferaseQuickGO ontologyBLASTP
20921562092635480phosphoribosylaminoimidazole carboxylase catalytic subunitQuickGO ontologyBLASTP
20928492093514666hypothetical protein
20939432094521579membrane associated proteinQuickGO ontologyBLASTP
20945412095230690transcriptional regulatory proteinQuickGO ontologyBLASTP
20953652095898534membrane associated proteinQuickGO ontology
20959152096358444hypothetical proteinBLASTP
20964992097230732ferredoxinQuickGO ontologyBLASTP
209727120984701200guanine-hypoxanthine permeaseQuickGO ontologyBLASTP
209898821004961509Na-linked D-alanine glycine permeaseQuickGO ontologyBLASTP