Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:1826977 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
182697718287791803hypothetical proteinBLASTP
18289671829794828flagellinQuickGO ontologyBLASTP
18302971830629333hypothetical proteinBLASTP
183064918323191671flagellar cap protein fliDQuickGO ontologyBLASTP
18323421832728387flagellar protein fliSQuickGO ontologyBLASTP
18330461833435390flagellinQuickGO ontologyBLASTP
18336601834139480hypothetical proteinBLASTP
18344191835369951flagellar hook-associated protein 3QuickGO ontologyBLASTP
183538218371211740flagellar hook-associated protein 1QuickGO ontologyBLASTP
18371541837561408hypothetical proteinBLASTP
183800318392531251flagellar motor switch proteinQuickGO ontologyBLASTP
18392341840232999flagellar motor switch protein fliMQuickGO ontologyBLASTP
18402491840653405putative chemotaxis protein cheWQuickGO ontologyBLASTP
18407231841082360chemotaxis protein cheYQuickGO ontologyBLASTP
18410981841703606chemotaxis protein cheCQuickGO ontologyBLASTP
184171018441062397chemotaxis protein cheAQuickGO ontologyBLASTP
18441191844892774chemotaxis protein methyltransferase cheRQuickGO ontologyBLASTP
18448671845658792protein-glutamate methylesteraseQuickGO ontologyBLASTP