Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:162670 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1626701640731404cell cycle protein mesJQuickGO ontologyBLASTP
164060164605546hypoxanthine-guanine phosphoribosyltransferaseQuickGO ontologyBLASTP
1647041665151812cell division protein ftsHQuickGO ontologyBLASTP
166633167016384dihydrolipoamide acyltransferaseQuickGO ontologyBLASTP
167196167984789putative transcriptional regulatorQuickGO ontologyBLASTP
167984168952969nitrogen regulation protein nifR3QuickGO ontologyBLASTP
168979169842864hypothetical proteinBLASTP
169858170418561transcription elongation factor GreAQuickGO ontologyBLASTP
1704351719431509lysyl-tRNA synthetaseQuickGO ontologyBLASTP
17215017222475tRNA-AsnQuickGO ontology
1725081738991392glycyl-tRNA synthetaseQuickGO ontologyBLASTP
1742621756561395UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseQuickGO ontologyBLASTP
176113177621150916S ribosomal RNAQuickGO ontologyBLASTP
177886180730284523S ribosomal RNAQuickGO ontologyBLASTP
179742180398657hypothetical proteinBLASTP