Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:1553000 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
15530271553614588hypothetical proteinBLASTP
15536941554401708putative transcriptional regulatory proteinQuickGO ontologyBLASTP
15556581556308651hypothetical proteinBLASTP
155630815579061599acetaldehyde dehydrogenase acetylatingQuickGO ontologyBLASTP
15579411558630690carbon dioxide concentrating mechanism protein ccmK homologQuickGO ontologyBLASTP
15586611559329669transcriptional regulatorQuickGO ontologyBLASTP
15599241560796873ethanolamine utilization protein eutJQuickGO ontologyBLASTP
15607541561422669hypothetical proteinBLASTP
15614291561872444lysine-sensitive aspartokinase IIIQuickGO ontologyBLASTP
15618691562222354ethanolamine utilization protein eutSQuickGO ontologyBLASTP
15622621563224963benzylsuccinate synthase activating enzymeQuickGO ontologyBLASTP
156323715657772541formate acetyltransferase 2QuickGO ontologyBLASTP
15661451566534390hypothetical protein
156690215680171116membrane spanning proteinQuickGO ontologyBLASTP
15684611569303843transcriptional regulatory proteinQuickGO ontologyBLASTP
156937415705221149acetaldehyde dehydrogenaseQuickGO ontologyBLASTP