Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:1141558 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
11415581142370813kilA protein putative phage-related DNA binding proteinQuickGO ontologyBLASTP
11424031142819417hypothetical protein
11431731143622450hypothetical proteinBLASTP
114370811450511344hypothetical proteinBLASTP
11450531145859807hypothetical proteinBLASTP
11460491146927879phage proteinQuickGO ontologyBLASTP
11469401147314375hypothetical protein
11473961147824429hypothetical proteinBLASTP
11478211148450630hypothetical proteinBLASTP
11486251149074450general stress protein 20UQuickGO ontologyBLASTP
11502701150581312hypothetical protein
11505931151060468hypothetical proteinBLASTP
115254511536331089hypothetical proteinBLASTP
11536791154602924phage terminase small subunitQuickGO ontologyBLASTP
115459211559351344phage terminase large subunitQuickGO ontologyBLASTP
115593511573921458hypothetical proteinBLASTP
11574491157922474membrane spanning proteinQuickGO ontologyBLASTP
115795911596591701hypothetical proteinBLASTP