Pre_GI Gene

Some Help

Host: NC_004432 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004432:32500 Mycoplasma penetrans HF-2, complete genome

Host Lineage: Mycoplasma penetrans; Mycoplasma; Mycoplasmataceae; Mycoplasmatales; Tenericutes; Bacteria

General Information: This strain has been isolated from the tracheal aspirate of a previously healthy HIV-negative patient with severe respiratory symptoms caused by this infection. Causes urogenital and respiratory disease. This genus currently comprises more than 120 obligate parasitic species found in a wide spectrum of hosts, including humans, animals, insects and plants. The primary habitats of human and animal mycoplasmas are mucous membranes of the respiratory and urogenital tracts, eyes, mammary glands and the joints. Infection that proceeds through attachment of the bacteria to the host cell via specialized surface proteins, adhesins, and subsequent invasion, results in prolonged intracellular persistence that may cause lethality. Once detected in association with their eukaryotic host tissue, most mycoplasmas can be cultivated in the absence of a host if their extremely fastidious growth requirements are met. The latter is one of the major traits that puts them in the separate taxonomic group of microorganisms, class Mollicutes. The cell membrane is rich in protein components (up to two thirds of the membrane mass) that largely consists of highly structurally adaptive lipoproteins employed in invading the host immune system, attachment to the host cells, and pathogenic invasion. Cell division proceeds via normal binary fission or via elongation of a parental cell to form multinucleated filaments and the subsequent breakup to form coccoid bodies.Mycoplasmas carry the smallest genomes of self-replicating cells (less than 500 recognizable coding regions), which is one of the reasons they were among the first microorganisms selected for the genome-sequencing projects. During their evolution, mycoplasmas appear to have lost all of the genes involved in amino acid and cofactor biosynthesis, synthesis of the cell wall and lipid metabolism, resulting in a requirement for the full spectrum of substrates and cofactors taken up from the host or from the complex artificial culture medium. They have lost a number of genes involved in cellular processes, such as cell division, heat shock response, regulatory genes, the two-component signal transduction systems, histidine protein kinases or their target response regulators, and most transcription factors. The majority of mycoplasmas are deficient in genes coding for components of intermediary and energy metabolism and thus are dependent mostly on glycolysis as an ATP-generating pathway. This organism infects humans in the urogenital and respiratory tracts though invasion of tissues. The disease is mainly associated with HIV-1 infection, particularly in the homosexual population, and is very persistent and believed to contribute to the deterioration of the immune system during HIV. Mycoplasma penetrans infection has also been suggested to be a primary cause of some forms of human urethritis and respiratory disease in non-HIV individuals.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
32759340781320cysteinyl-tRNA synthetaseQuickGO ontologyBLASTP
3408634802717rRNA methylaseQuickGO ontologyBLASTP
3479335407615hypothetical protein
356283609546850S ribosomal protein L11QuickGO ontologyBLASTP
3610637116101150S ribosomal protein L1QuickGO ontologyBLASTP
3715738092936glycosyltransferaseQuickGO ontologyBLASTP
3810438559456hypothetical protein
391623958442330S ribosomal protein S12QuickGO ontologyBLASTP
395994006646830S ribosomal protein S7QuickGO ontologyBLASTP
40085421332049elongation factor GQuickGO ontologyBLASTP
42293434771185elongation factor TuQuickGO ontologyBLASTP
43741447571017hypothetical protein
4486045213354hypothetical protein
4518245544363holo-acyl carrier protein synthaseQuickGO ontology
4568545951267hypothetical protein
46091469038131-acyl-sn-glycerol-3-phosphate acyltransferaseQuickGO ontologyBLASTP
4692047795876hypothetical proteinBLASTP
4778548378594segregation and condensation protein BQuickGO ontologyBLASTP
4838848615228hypothetical proteinBLASTP
4861549175561predicted GTP-binding proteinQuickGO ontologyBLASTP
49185518032619valyl-tRNA synthetaseQuickGO ontologyBLASTP
52584536781095predicted competence proteinQuickGO ontology
53570555702001hypothetical protein
5558356521939hypothetical protein
56499578421344putative integral membrane proteinQuickGO ontology