Pre_GI Gene

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Host: NC_004432 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004432:1310322 Mycoplasma penetrans HF-2, complete genome

Host Lineage: Mycoplasma penetrans; Mycoplasma; Mycoplasmataceae; Mycoplasmatales; Tenericutes; Bacteria

General Information: This strain has been isolated from the tracheal aspirate of a previously healthy HIV-negative patient with severe respiratory symptoms caused by this infection. Causes urogenital and respiratory disease. This genus currently comprises more than 120 obligate parasitic species found in a wide spectrum of hosts, including humans, animals, insects and plants. The primary habitats of human and animal mycoplasmas are mucous membranes of the respiratory and urogenital tracts, eyes, mammary glands and the joints. Infection that proceeds through attachment of the bacteria to the host cell via specialized surface proteins, adhesins, and subsequent invasion, results in prolonged intracellular persistence that may cause lethality. Once detected in association with their eukaryotic host tissue, most mycoplasmas can be cultivated in the absence of a host if their extremely fastidious growth requirements are met. The latter is one of the major traits that puts them in the separate taxonomic group of microorganisms, class Mollicutes. The cell membrane is rich in protein components (up to two thirds of the membrane mass) that largely consists of highly structurally adaptive lipoproteins employed in invading the host immune system, attachment to the host cells, and pathogenic invasion. Cell division proceeds via normal binary fission or via elongation of a parental cell to form multinucleated filaments and the subsequent breakup to form coccoid bodies.Mycoplasmas carry the smallest genomes of self-replicating cells (less than 500 recognizable coding regions), which is one of the reasons they were among the first microorganisms selected for the genome-sequencing projects. During their evolution, mycoplasmas appear to have lost all of the genes involved in amino acid and cofactor biosynthesis, synthesis of the cell wall and lipid metabolism, resulting in a requirement for the full spectrum of substrates and cofactors taken up from the host or from the complex artificial culture medium. They have lost a number of genes involved in cellular processes, such as cell division, heat shock response, regulatory genes, the two-component signal transduction systems, histidine protein kinases or their target response regulators, and most transcription factors. The majority of mycoplasmas are deficient in genes coding for components of intermediary and energy metabolism and thus are dependent mostly on glycolysis as an ATP-generating pathway. This organism infects humans in the urogenital and respiratory tracts though invasion of tissues. The disease is mainly associated with HIV-1 infection, particularly in the homosexual population, and is very persistent and believed to contribute to the deterioration of the immune system during HIV. Mycoplasma penetrans infection has also been suggested to be a primary cause of some forms of human urethritis and respiratory disease in non-HIV individuals.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13103221311140819short-chain alcohol dehydrogenase family enzymeQuickGO ontologyBLASTP
13111331311744612hypothetical protein
131171713131861470aminopeptidase CQuickGO ontologyBLASTP
131318813147321545aminopeptidase CQuickGO ontologyBLASTP
13148011315160360ribosomal protein L17QuickGO ontologyBLASTP
13151711316166996DNA-directed RNA polymerase alpha subunitQuickGO ontologyBLASTP
1316181131655237230S ribosomal protein S11QuickGO ontologyBLASTP
1316568131694237530S ribosomal protein S13QuickGO ontologyBLASTP
13170931317311219translation initiation factor IF-1QuickGO ontologyBLASTP
13173191318059741methionine aminopeptidaseQuickGO ontologyBLASTP
13180621318709648adenylate kinaseQuickGO ontologyBLASTP
131872113201421422preprotein translocase SecYQuickGO ontologyBLASTP
13201661320609444ribosomal protein L15QuickGO ontologyBLASTP
1320613132131770530S ribosomal protein S5QuickGO ontologyBLASTP
1321339132169836050S ribosomal protein L18QuickGO ontologyBLASTP
1321714132226555250S ribosomal protein L6QuickGO ontologyBLASTP
13222761322671396ribosomal protein S8QuickGO ontologyBLASTP
13226881322873186ribosomal protein S14QuickGO ontologyBLASTP
1322875132343856450S ribosomal protein L5QuickGO ontologyBLASTP
13234471323770324ribosomal protein L24QuickGO ontologyBLASTP
13237831324151369ribosomal protein L14QuickGO ontologyBLASTP
13241821324457276ribosomal protein S17QuickGO ontologyBLASTP
132447613257291254ribosomal protein S3QuickGO ontologyBLASTP
13257321326466735ribosomal protein L29QuickGO ontologyBLASTP
1326453132687542350S ribosomal protein L16QuickGO ontologyBLASTP
132689813279231026ribosomal protein L22QuickGO ontologyBLASTP
13279411328174234ribosomal protein S19QuickGO ontologyBLASTP
1328232132907184050S ribosomal protein L2QuickGO ontologyBLASTP
1329106132952241750S ribosomal protein L23QuickGO ontologyBLASTP
1329522133016364250S ribosomal protein L4QuickGO ontologyBLASTP
1330163133114398150S ribosomal protein L3QuickGO ontologyBLASTP
1331115133150439030S ribosomal protein S10QuickGO ontologyBLASTP
13316941332524831haloacid dehalogenase-like hydrolaseQuickGO ontologyBLASTP
13325461333313768predicted transcriptional regulatorQuickGO ontologyBLASTP
13333371333993657ribonuclease HIIQuickGO ontologyBLASTP
13340471334565519adenine phosphoribosyltransferaseQuickGO ontologyBLASTP
133457513379583384predicted protein-export membrane protein SecDQuickGO ontology
133807413405422469cell division protein FtsHQuickGO ontologyBLASTP
13405961341129534hypoxanthine-guanine phosphoribosyltransferaseQuickGO ontologyBLASTP
13412271341724498putative enzyme of deoxy-xylulose pathway YgbBQuickGO ontologyBLASTP