Pre_GI Gene

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Host: NC_004337 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004337:4374500 Shigella flexneri 2a str. 301, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
43747334375635903minor fimbrial subunit D-mannose specific adhesinQuickGO ontologyBLASTP
43756554376158504minor fimbrial subunit precursor polypeptideQuickGO ontologyBLASTP
43761714376701531minor fimbrial subunit precursor polypeptideQuickGO ontologyBLASTP
43787754379170396IS1 ORF2QuickGO ontologyBLASTP
43791974379472276IS1 ORF1QuickGO ontologyBLASTP
43801904380915726periplasmic chaperoneQuickGO ontologyBLASTP
43809524381590639fimbrial proteinQuickGO ontologyBLASTP
43815564382104549major type 1 subunit fimbrin pilinQuickGO ontologyBLASTP
43825854383181597recombinase regulator for fimAQuickGO ontologyBLASTP
43837764384261486recombinase regulator for fimAQuickGO ontologyBLASTP
43858834386431549hypothetical proteinBLASTP
438634343875571215hypothetical proteinBLASTP
43878444388602759hypothetical proteinBLASTP
43890714389466396IS1 ORF2QuickGO ontologyBLASTP
43894934389768276IS1 ORF1QuickGO ontologyBLASTP
43898634390558696putative deoR family transcriptional regulatorQuickGO ontologyBLASTP
43910284391312285hypothetical proteinBLASTP
43913694392181813hypothetical proteinBLASTP
43925014392824324putative IS1 encoded proteinQuickGO ontologyBLASTP
43928994393402504IS1 ORF2QuickGO ontologyBLASTP
43935594393897339IS911 ORF1QuickGO ontologyBLASTP
43939244394763840IS911 ORF2QuickGO ontologyBLASTP
439473843959491212putative P4-type integraseQuickGO ontologyBLASTP
4396148439623285tRNA-LeuQuickGO ontologyBLASTP
439638643974471062putative oxidoreductaseQuickGO ontologyBLASTP
439752843990781551hypothetical proteinBLASTP