Pre_GI Gene

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Host: NC_004337 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004337:3761865 Shigella flexneri 2a str. 301, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
37618653762260396IS1 ORF2QuickGO ontologyBLASTP
37622873762562276IS1 ORF1QuickGO ontologyBLASTP
376279237638171026L-threonine 3-dehydrogenaseQuickGO ontologyBLASTP
3763827376502311972-amino-3-ketobutyrate coenzyme A ligaseQuickGO ontologyBLASTP
37652983766155858involved in lipopolysaccharide biosynthesisQuickGO ontologyBLASTP
37664593767391933ADP-L-glycero-D-mannoheptose-6-epimeraseQuickGO ontologyBLASTP
376740137684471047ADP-heptose--lps heptosyltransferase IIQuickGO ontologyBLASTP
37684813769443963heptosyl transferase IQuickGO ontologyBLASTP
376944037706481209lipid A-core surface polymer ligaseQuickGO ontologyBLASTP
377068437718261143lipopolysaccharide 12-N- acetylglucosaminetransferaseQuickGO ontologyBLASTP
377183537728481014putative UDP-glucosegalactosyl LPS alpha12-glucosyltransferaseQuickGO ontologyBLASTP
37728733773580708putative LPS biosynthesis proteinQuickGO ontologyBLASTP
377360637746131008UDP-D-galactoseglucosyllipopolysaccharide- alpha-13-D-galactosyltransferaseQuickGO ontologyBLASTP
37746563775462807lipopolysaccharide core biosynthesis proteinQuickGO ontologyBLASTP
377544637765701125LPS alpha13-glucosyltransferaseQuickGO ontologyBLASTP
377656737776251059lipopolysaccharide core biosynthesis proteinQuickGO ontologyBLASTP
37779833778378396IS1 ORF2QuickGO ontologyBLASTP
37784053778680276IS1 ORF1QuickGO ontologyBLASTP
3778854378013112783-deoxy-D-manno-octulosonic-acid transferaseQuickGO ontologyBLASTP
37801393780618480phosphopantetheine adenylyltransferaseQuickGO ontologyBLASTP
37806573781466810formamidopyrimidine-DNA glycosylaseQuickGO ontologyBLASTP
3781564378173116850S ribosomal protein L33QuickGO ontologyBLASTP
3781752378198823750S ribosomal protein L28QuickGO ontologyBLASTP
37822053782873669DNA repair protein RadCQuickGO ontologyBLASTP
378297337842651293phosphopantothenoylcysteine synthasedecarboxylaseQuickGO ontologyBLASTP
37842433784701459deoxyuridine 5-triphosphate nucleotidohydrolaseQuickGO ontologyBLASTP
37847663785404639nucleoid occlusion proteinQuickGO ontologyBLASTP
37854413786082642orotate phosphoribosyltransferaseQuickGO ontologyBLASTP