Pre_GI Gene

Some Help

Host: NC_004337 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004337:367687 Shigella flexneri 2a str. 301, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
36768736954918631-deoxy-D-xylulose-5-phosphate synthaseQuickGO ontologyBLASTP
369574370473900geranyltranstransferase farnesyldiphosphate synthaseQuickGO ontologyBLASTP
370473370715243exodeoxyribonuclease VII small subunitQuickGO ontologyBLASTP
3709213722911371thiamine biosynthesis protein ThiIQuickGO ontologyBLASTP
3724243730205974-methyl-5b-hydroxyethyl-thiazole monophosphate biosynthesis ThiJ proteinQuickGO ontologyBLASTP
3729773738889122-dehydropantoate 2-reductaseQuickGO ontologyBLASTP
374056374547492hypothetical proteinBLASTP
3746073763371731hypothetical proteinBLASTP
3763903785432154hypothetical proteinBLASTP
378888379391504IS1 ORF2QuickGO ontologyBLASTP
379439379678240hypothetical proteinBLASTP
379972380283312hypothetical proteinBLASTP
380467381354888protoheme IX farnesyltransferaseQuickGO ontologyBLASTP
381369381698330cytochrome o ubiquinol oxidase subunit IVQuickGO ontologyBLASTP
381698382312615cytochrome o ubiquinol oxidase subunit IIIQuickGO ontologyBLASTP
384845385651807ISSfl4 ORF3QuickGO ontologyBLASTP
385781386128348ISSfl4 ORF2QuickGO ontologyBLASTP
386125386799675ISSfl4 ORF1QuickGO ontologyBLASTP
3871693886441476beta-lactamase induction signal transducer AmpGQuickGO ontologyBLASTP
388688389368681putative polymeraseproteinaseQuickGO ontologyBLASTP
389538389888351possible regulator of murein genesQuickGO ontologyBLASTP
389822390085264hypothetical proteinBLASTP
3902323915301299trigger factorQuickGO ontologyBLASTP