Pre_GI Gene

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Host: NC_004337 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004337:3621985 Shigella flexneri 2a str. 301, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
362198536233371353glutathione reductaseQuickGO ontologyBLASTP
36242503624645396IS1 ORF2QuickGO ontologyBLASTP
36246723624947276IS1 ORF1QuickGO ontologyBLASTP
36249893625534546hypothetical proteinBLASTP
362540136266901290arsenical pump membrane proteinQuickGO ontologyBLASTP
36267033627128426arsenate reductaseQuickGO ontologyBLASTP
36274783627981504IS1 ORF2QuickGO ontologyBLASTP
36280123628968957hypothetical proteinBLASTP
362954936307721224hypothetical proteinBLASTP
36309863631585600outer membrane protein induced after carbon starvationQuickGO ontologyBLASTP
36317413632271531hypothetical proteinBLASTP
36330233633361339hypothetical proteinBLASTP
36334653633797333hypothetical proteinBLASTP
36340523634624573hypothetical proteinBLASTP
36354233635950528hypothetical proteinBLASTP
36373473637742396IS1 ORF2QuickGO ontologyBLASTP
36377693638044276IS1 ORF1QuickGO ontologyBLASTP
363831536399641650cytoplasmic trehalaseQuickGO ontologyBLASTP
36414523642054603putative regulatorQuickGO ontologyBLASTP
36425023643473972putative transcriptional regulator LYSR-typeQuickGO ontologyBLASTP
364352236445351014hypothetical proteinBLASTP
364494636462681323putative transport proteinQuickGO ontologyBLASTP