Pre_GI Gene

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Host: NC_004337 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004337:3249791 Shigella flexneri 2a str. 301, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
324979132511551365putative L-serine deaminaseQuickGO ontologyBLASTP
32512273251616390hypothetical proteinBLASTP
325163032539242295probable formate acetyltransferase 3QuickGO ontologyBLASTP
325395832551661209acetatepropionate kinaseQuickGO ontologyBLASTP
325519232565231332anaerobically inducible permease for L-threonine and L-serineQuickGO ontologyBLASTP
32565453257534990threonine dehydrataseQuickGO ontologyBLASTP
32576333258571939transcriptional activator of tdc operonQuickGO ontologyBLASTP
32587613259105345threonine dehydratase operon activator proteinQuickGO ontologyBLASTP
326211932633451227hypothetical proteinBLASTP
32633613264260900putative dehydrogenaseQuickGO ontologyBLASTP
326506732664011335putative transport proteinQuickGO ontologyBLASTP
326677632683471572putative hydrolaseQuickGO ontologyBLASTP
32683993269223825putative DEOR-type transcriptional regulator of aga operonQuickGO ontologyBLASTP
326947232707521281putative tagatose 6-phosphate kinase 2QuickGO ontologyBLASTP
32707393271248510cytoplasmic transport protein N-acetylgalactosamine-specific IIB component 2 EIIB-AGAQuickGO ontologyBLASTP
32712593272038780N-acetylgalactosameine-specific IIC component 2QuickGO ontologyBLASTP
32720283272837810putative transport enzyme subunitQuickGO ontologyBLASTP