Pre_GI Gene

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Host: NC_004337 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004337:309833 Shigella flexneri 2a str. 301, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3098333110861254gamma-glutamyl phosphate reductaseQuickGO ontologyBLASTP
31120131127676tRNA-ThrQuickGO ontologyBLASTP
311291311755465putative phage integraseQuickGO ontologyBLASTP
311782312600819IS600 ORF2QuickGO ontologyBLASTP
312636312938303IS600 ORF1QuickGO ontologyBLASTP
312995313720726putative phage integraseQuickGO ontologyBLASTP
313947314252306hypothetical proteinBLASTP
314252314629378hypothetical bacteriophage proteinQuickGO ontologyBLASTP
314595315263669IS629 ORF2QuickGO ontologyBLASTP
315478315804327IS629 ORF1QuickGO ontologyBLASTP
316047316349303IS600 ORF1QuickGO ontologyBLASTP
316385317203819IS600 ORF2QuickGO ontologyBLASTP
317312317605294integraseQuickGO ontologyBLASTP
317867318229363putative flippaseQuickGO ontologyBLASTP
318226319155930putative bactoprenol glucosyl transferaseQuickGO ontologyBLASTP
3191523206121461putative glucosyl tranferase IIQuickGO ontologyBLASTP
3210023221921191hypothetical proteinBLASTP
3226433236921050hypothetical proteinBLASTP
324465324899435putative phage tail fibre proteinQuickGO ontologyBLASTP
324871325521651hypothetical bacteriophage proteinQuickGO ontologyBLASTP
325574326392819IS600 ORF2QuickGO ontologyBLASTP
326428326730303IS600 ORF1QuickGO ontologyBLASTP
3269163280791164putative phage integraseQuickGO ontologyBLASTP
3284283296001173hypothetical proteinBLASTP
329654330277624hypothetical proteinBLASTP
330404331222819IS600 ORF2QuickGO ontologyBLASTP
331258331620363IS600 ORF1QuickGO ontologyBLASTP
331586332254669IS629 ORF2QuickGO ontologyBLASTP
332469332795327IS629 ORF1QuickGO ontologyBLASTP
3329463340611116hypothetical proteinBLASTP
334078334887810pyrroline-5-carboxylate reductaseQuickGO ontologyBLASTP
334887335465579hypothetical proteinBLASTP
335648336172525shikimate kinase IIQuickGO ontologyBLASTP
336222336413192hypothetical proteinBLASTP
336671337348678protein of aro operonQuickGO ontologyBLASTP
337420337704285hypothetical proteinBLASTP
337913338194282hypothetical proteinBLASTP
338191338646456hypothetical proteinBLASTP