Pre_GI Gene

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Host: NC_004337 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004337:2747917 Shigella flexneri 2a str. 301, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
27479172748600684putative transport proteinQuickGO ontologyBLASTP
27486552749248594heat shock protein GrpEQuickGO ontologyBLASTP
27493712750249879inorganic polyphosphateATP-NAD kinaseQuickGO ontologyBLASTP
275033527519961662DNA repair protein RecNQuickGO ontologyBLASTP
27523342752486153small membrane protein AQuickGO ontologyBLASTP
27525482752838291hypothetical proteinBLASTP
27528282753265438hypothetical proteinBLASTP
27534362753918483SsrA-binding proteinQuickGO ontologyBLASTP
275470027559411242putative CP4-57-type integraseQuickGO ontologyBLASTP
27561412756416276IS1 ORF1QuickGO ontologyBLASTP
27564432756838396IS1 ORF2QuickGO ontologyBLASTP
27569482757256309IS3 ORF1QuickGO ontologyBLASTP
27572532758119867IS3 ORF2QuickGO ontologyBLASTP
2758367275844276tRNA-MetQuickGO ontologyBLASTP
276148427625211038hypothetical proteinBLASTP
276247527638091335hypothetical proteinBLASTP
2765447276657411284-aminobutyrate aminotransferaseQuickGO ontologyBLASTP
276674927680261278transport permease protein of gamma-aminobutyrateQuickGO ontologyBLASTP
27682332768895663putative transcriptional regulatorQuickGO ontologyBLASTP
27688962769345450hypothetical proteinBLASTP
27696882770593906insertion sequence 2 OrfB proteinQuickGO ontologyBLASTP
27705512770961411insertion sequence 2 OrfA proteinQuickGO ontologyBLASTP