Pre_GI Gene

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Host: NC_004337 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004337:2548288 Shigella flexneri 2a str. 301, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
25482882549157870N-acetylmuramoyl-l-alanine amidase IQuickGO ontologyBLASTP
25491612550060900coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
25511642551664501hypothetical proteinBLASTP
25516772552336660hypothetical proteinBLASTP
25535182554309792hypothetical proteinBLASTP
25550292555424396hypothetical proteinBLASTP
25554422555705264hypothetical proteinBLASTP
25557282556270543hypothetical proteinBLASTP
25563672556696330hypothetical proteinBLASTP
25575262557738213hypothetical proteinBLASTP
255799025594501461putative amino acid antiporterQuickGO ontologyBLASTP
25594722560293822similar to glutamate racemaseQuickGO ontologyBLASTP
25604122560807396iso-IS1 ORF2QuickGO ontologyBLASTP
256162525629981374hypothetical proteinBLASTP
25629732563452480hypothetical proteinBLASTP
25634652563872408hypothetical proteinBLASTP
256409325663722280phosphate acetyltransferaseQuickGO ontologyBLASTP
25666612567611951transaldolaseQuickGO ontologyBLASTP
256763125696342004transketolaseQuickGO ontologyBLASTP