Pre_GI Gene

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Host: NC_004337 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004337:2185282 Shigella flexneri 2a str. 301, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21852822186247966putative kinaseQuickGO ontologyBLASTP
218669221879001209iso-IS10R ORFQuickGO ontologyBLASTP
21883532189174822hypothetical proteinBLASTP
21892392190039801phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
21900362190824789hydroxyethylthiazole kinaseQuickGO ontologyBLASTP
21910472191319273hypothetical proteinBLASTP
21924902192828339hypothetical proteinBLASTP
21931282193943816putative type-1 fimbrial proteinQuickGO ontologyBLASTP
219395921964392481putative outer membrane proteinQuickGO ontologyBLASTP
21969912197218228IS1 ORF1QuickGO ontologyBLASTP
21972632197640378IS1 ORF2QuickGO ontologyBLASTP
21979862198510525putative fimbrial-like proteinQuickGO ontologyBLASTP
21987862199181396IS1 ORF2QuickGO ontologyBLASTP
21992082199483276IS1 ORF1QuickGO ontologyBLASTP
220012322012321110putative ATPaseQuickGO ontologyBLASTP
220136422033972034methionyl-tRNA synthetaseQuickGO ontologyBLASTP
22037932204095303IS600 ORF1QuickGO ontologyBLASTP
22041312204949819IS600 ORF2QuickGO ontologyBLASTP
22056072205882276IS1 ORF1QuickGO ontologyBLASTP
22059092206304396IS1 ORF2QuickGO ontologyBLASTP