Pre_GI Gene

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Host: NC_004337 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004337:2098736 Shigella flexneri 2a str. 301, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
209743520987391305histidinol dehydrogenaseQuickGO ontologyBLASTP
209873620998061071histidinol-phosphate aminotransferaseQuickGO ontologyBLASTP
209980621008731068imidazole glycerol-phosphate dehydratasehistidinol phosphataseQuickGO ontologyBLASTP
21008732101463591imidazole glycerol phosphate synthase subunit HisHQuickGO ontologyBLASTP
210146321022007381-5-phosphoribosyl-5-5- phosphoribosylaminomethylideneamino imidazole-4-carboxamide isomeraseQuickGO ontologyBLASTP
21021822102958777imidazole glycerol phosphate synthase subunit HisFQuickGO ontologyBLASTP
21029522103563612bifunctional phosphoribosyl-AMP cyclohydrolasephosphoribosyl-ATP pyrophosphatase proteinQuickGO ontologyBLASTP
210374921047621014regulator of length of O-antigen component of lipopolysaccharide chainsQuickGO ontologyBLASTP
2106242210764814076-phosphogluconate dehydrogenaseQuickGO ontologyBLASTP
21081132108664552hypothetical proteinBLASTP
21087652109364600hypothetical proteinBLASTP
21095812110072492hypothetical proteinBLASTP
21101302110519390glycosyl transferaseQuickGO ontologyBLASTP
21105822110956375glycosyl translocaseQuickGO ontologyBLASTP
211096021121081149O-antigen polymeraseQuickGO ontologyBLASTP
21121282112997870dTDP-rhamnosyl transferaseQuickGO ontologyBLASTP
21130262113916891dTDP-rhamnosyl transferaseQuickGO ontologyBLASTP
211394621152021257polysaccharide biosynthesis proteinQuickGO ontologyBLASTP
21152182115763546dTDP-6-deoxy-L-mannose-dehydrogenaseQuickGO ontologyBLASTP
21157682116646879glucose-1-phosphate thymidylyltransferaseQuickGO ontologyBLASTP
21167052117604900dTDP-6-deoxy-L-mannose-dehydrogenaseQuickGO ontologyBLASTP
211760421186891086dTDP-glucose 46 dehydrataseQuickGO ontologyBLASTP
21190622119955894UTP--glucose-1-P uridyltransferaseQuickGO ontologyBLASTP
212013021215241395hypothetical proteinBLASTP
212153521227551221putative colanic acid biosynthesis glycosyl transferaseQuickGO ontologyBLASTP
212275221240321281putative galactokinaseQuickGO ontologyBLASTP
212421221256901479probable export proteinQuickGO ontologyBLASTP
212569221270861395putative colanic acid biosynthsis UDP-glucose lipid carrier transferaseQuickGO ontologyBLASTP
212714121285111371phosphomannomutaseQuickGO ontologyBLASTP