Pre_GI Gene

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Host: NC_004337 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004337:2035945 Shigella flexneri 2a str. 301, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
20350822035987906insertion sequence 2 OrfB proteinQuickGO ontologyBLASTP
20359452036355411insertion sequence 2 OrfA proteinQuickGO ontologyBLASTP
20372112037486276IS1 ORF1QuickGO ontologyBLASTP
20375132037908396IS1 ORF2QuickGO ontologyBLASTP
20379542038805852chaperone protein HchAQuickGO ontologyBLASTP
203891320402711359putative 2-component sensor proteinQuickGO ontologyBLASTP
20402712040942672putative 2-component transcriptional regulatorQuickGO ontologyBLASTP
20410752041488414hypothetical proteinBLASTP
20426022043237636hypothetical proteinBLASTP
20434952044145651hypothetical proteinBLASTP
20455492046217669hypothetical proteinBLASTP
204725320484611209iso-IS10R ORFQuickGO ontologyBLASTP
20496942050071378hypothetical bacteriophage proteinQuickGO ontologyBLASTP
205021420512481035IS600 ORF2QuickGO ontologyBLASTP
20513232051826504IS1 ORF2QuickGO ontologyBLASTP
20519192052401483hypothetical proteinBLASTP
205246920544181950putative tail proteinQuickGO ontologyBLASTP
20545032054838336hypothetical bacteriophage proteinQuickGO ontologyBLASTP
20548382055194357hypothetical bacteriophage proteinQuickGO ontologyBLASTP
205519420566901497putative sheath proteinQuickGO ontologyBLASTP