Pre_GI Gene

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Host: NC_004337 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004337:1783645 Shigella flexneri 2a str. 301, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
178364517846551011alcohol dehydrogenaseQuickGO ontologyBLASTP
17847231785085363hypothetical proteinBLASTP
17853131785966654formate dehydrogenase-N nitrate-inducible cytochrome B556Fdn gamma subunitQuickGO ontologyBLASTP
17859591786843885formate dehydrogenase-N nitrate-inducible iron-sulfur beta subunitQuickGO ontologyBLASTP
17901351791016882hypothetical proteinBLASTP
17912191791614396IS1 ORF2QuickGO ontologyBLASTP
17916411791916276IS1 ORF1QuickGO ontologyBLASTP
179204817931481101putative outer membrane porin proteinQuickGO ontologyBLASTP
17933121793797486hypothetical proteinBLASTP
17939071794896990putative glycoproteinQuickGO ontologyBLASTP
17951841795459276IS1 ORF1QuickGO ontologyBLASTP
17954861795881396IS1 ORF2QuickGO ontologyBLASTP
179633917977271389nitrite extrusion protein 2QuickGO ontologyBLASTP
18015461802478933nitrate reductase 1 beta subunitQuickGO ontologyBLASTP
18024561802878423putative IS91 ORF2QuickGO ontologyBLASTP
180287818040651188IS91 ORFQuickGO ontologyBLASTP
18043361805058723hypothetical proteinBLASTP
180516318063591197putative oxidoreductaseQuickGO ontologyBLASTP