Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:4202247 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
42022474202783537hypothetical proteinBLASTP
420348942046851197hypothetical proteinBLASTP
420469642057421047peptidaseQuickGO ontologyBLASTP
420588842070421155hypothetical proteinBLASTP
420703942084271389hypothetical proteinBLASTP
4208533420862896transposaseQuickGO ontologyBLASTP
42086694208866198hypothetical proteinBLASTP
42090684209355288hypothetical proteinBLASTP
420969942110721374hypothetical proteinBLASTP
42110444211766723hypothetical proteinBLASTP
421181642131411326methyltransferaseQuickGO ontologyBLASTP
42131544213621468hypothetical proteinBLASTP
42132804213543264transposaseQuickGO ontologyBLASTP
42135694213763195hypothetical proteinBLASTP
421416542154811317hypothetical proteinBLASTP
421547842175442067hypothetical proteinBLASTP
421767542186971023transposaseQuickGO ontologyBLASTP
42186944219476783transposaseIS proteinQuickGO ontologyBLASTP
42195504219987438D-tyrosyl-tRNA deacylaseQuickGO ontologyBLASTP
42199944220938945ribonuclease BNQuickGO ontologyBLASTP
42209754221565591phosphataseQuickGO ontologyBLASTP
422188742237101824GTP-binding factorQuickGO ontologyBLASTP
422424842256811434glutamine synthetaseQuickGO ontologyBLASTP