Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:4116676 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
411667641178601185NaH antiporter pH dependentQuickGO ontologyBLASTP
411810341192421140chaperone with DnaK heat shock proteinQuickGO ontologyBLASTP
411935441212641911molecular chaperone DnaKQuickGO ontologyBLASTP
41216384122249612hypothetical proteinBLASTP
412253841249852448hypothetical proteinBLASTP
412505541264431389prolinebetaine transporterQuickGO ontologyBLASTP
41265714127158588molybdenum cofactor biosynthesis proteinQuickGO ontologyBLASTP
41272444127402159hypothetical proteinBLASTP
41274464128438993transaldolaseQuickGO ontologyBLASTP
41284664128648183hypothetical proteinBLASTP
41289284129707780hypothetical proteinBLASTP
413052441318131290threonine synthaseQuickGO ontologyBLASTP
41318174132767951homoserine kinaseQuickGO ontologyBLASTP
413274941352862538bifunctional aspartokinase Ihomeserine dehydrogenase IQuickGO ontologyBLASTP
41344704134628159hypothetical protein