Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:4073698 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
407369840760462349hypothetical proteinBLASTP
40737834074103321hypothetical protein
40741074074439333hypothetical protein
407615040787532604ATP-dependent proteaseQuickGO ontologyBLASTP
407875640797781023hypothetical proteinBLASTP
407973240815761845hypothetical proteinBLASTP
40816094082052444hypothetical proteinBLASTP
40821264082644519hypothetical proteinBLASTP
408280740843181512hypothetical proteinBLASTP
40843184084878561hypothetical proteinBLASTP
408488940859021014hypothetical proteinBLASTP
40862324086975744hypothetical proteinBLASTP
40881984088818621hypothetical proteinBLASTP
40891164089949834Dna-J like membrane chaperone proteinQuickGO ontologyBLASTP
409009840924762379organic solvent tolerance protein precursorQuickGO ontologyBLASTP
409254440938481305survival proteinQuickGO ontologyBLASTP
4093820409482710084-hydroxythreonine-4-phosphate dehydrogenaseQuickGO ontologyBLASTP
40948204095638819dimethyladenosine transferaseQuickGO ontologyBLASTP
40956524096029378hypothetical proteinBLASTP
40960464096915870diadenosinetetraphosphataseQuickGO ontologyBLASTP
40970054097469465hypothetical proteinBLASTP